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Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non-BRCA1/2-Mutant Cancers.
Yap, Timothy A; Kristeleit, Rebecca; Michalarea, Vasiliki; Pettitt, Stephen J; Lim, Joline S J; Carreira, Suzanne; Roda, Desamparados; Miller, Rowan; Riisnaes, Ruth; Miranda, Susana; Figueiredo, Ines; Rodrigues, Daniel Nava; Ward, Sarah; Matthews, Ruth; Parmar, Mona; Turner, Alison; Tunariu, Nina; Chopra, Neha; Gevensleben, Heidrun; Turner, Nicholas C; Ruddle, Ruth; Raynaud, Florence I; Decordova, Shaun; Swales, Karen E; Finneran, Laura; Hall, Emma; Rugman, Paul; Lindemann, Justin P O; Foxley, Andrew; Lord, Christopher J; Banerji, Udai; Plummer, Ruth; Basu, Bristi; Lopez, Juanita S; Drew, Yvette; de Bono, Johann S.
Afiliação
  • Yap TA; Royal Marsden Hospital, London, United Kingdom. tyap@mdanderson.org.
  • Kristeleit R; The Institute of Cancer Research, London, United Kingdom.
  • Michalarea V; University College London, London, United Kingdom.
  • Pettitt SJ; Royal Marsden Hospital, London, United Kingdom.
  • Lim JSJ; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Carreira S; The CRUK Gene Function Laboratory, The Institute of Cancer Research, London, United Kingdom.
  • Roda D; Royal Marsden Hospital, London, United Kingdom.
  • Miller R; The Institute of Cancer Research, London, United Kingdom.
  • Riisnaes R; Royal Marsden Hospital, London, United Kingdom.
  • Miranda S; The Institute of Cancer Research, London, United Kingdom.
  • Figueiredo I; University College London, London, United Kingdom.
  • Rodrigues DN; The Institute of Cancer Research, London, United Kingdom.
  • Ward S; The Institute of Cancer Research, London, United Kingdom.
  • Matthews R; The Institute of Cancer Research, London, United Kingdom.
  • Parmar M; The Institute of Cancer Research, London, United Kingdom.
  • Turner A; Royal Marsden Hospital, London, United Kingdom.
  • Tunariu N; The Institute of Cancer Research, London, United Kingdom.
  • Chopra N; Royal Marsden Hospital, London, United Kingdom.
  • Gevensleben H; The Institute of Cancer Research, London, United Kingdom.
  • Turner NC; Royal Marsden Hospital, London, United Kingdom.
  • Ruddle R; The Institute of Cancer Research, London, United Kingdom.
  • Raynaud FI; Royal Marsden Hospital, London, United Kingdom.
  • Decordova S; The Institute of Cancer Research, London, United Kingdom.
  • Swales KE; Royal Marsden Hospital, London, United Kingdom.
  • Finneran L; Royal Marsden Hospital, London, United Kingdom.
  • Hall E; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Rugman P; The Institute of Cancer Research, London, United Kingdom.
  • Lindemann JPO; Royal Marsden Hospital, London, United Kingdom.
  • Foxley A; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.
  • Lord CJ; The Institute of Cancer Research, London, United Kingdom.
  • Banerji U; The Institute of Cancer Research, London, United Kingdom.
  • Plummer R; The Institute of Cancer Research, London, United Kingdom.
  • Basu B; The Institute of Cancer Research, London, United Kingdom.
  • Lopez JS; The Institute of Cancer Research, London, United Kingdom.
  • Drew Y; The Institute of Cancer Research, London, United Kingdom.
  • de Bono JS; Oncology R&D, AstraZeneca, Cambridge, United Kingdom.
Cancer Discov ; 10(10): 1528-1543, 2020 10.
Article em En | MEDLINE | ID: mdl-32532747
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ftalazinas / Piperazinas / Pirimidinas / Pirróis / Protocolos de Quimioterapia Combinada Antineoplásica / Proteína BRCA1 / Proteína BRCA2 / Inibidores de Poli(ADP-Ribose) Polimerases Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ftalazinas / Piperazinas / Pirimidinas / Pirróis / Protocolos de Quimioterapia Combinada Antineoplásica / Proteína BRCA1 / Proteína BRCA2 / Inibidores de Poli(ADP-Ribose) Polimerases Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article