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Gene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes.
Renner, Steffen; Bergsdorf, Christian; Bouhelal, Rochdi; Koziczak-Holbro, Magdalena; Amati, Andrea Marco; Techer-Etienne, Valerie; Flotte, Ludivine; Reymann, Nicole; Kapur, Karen; Hoersch, Sebastian; Oakeley, Edward James; Schuffenhauer, Ansgar; Gubler, Hanspeter; Lounkine, Eugen; Farmer, Pierre.
Afiliação
  • Renner S; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland. steffen.renner@novartis.com.
  • Bergsdorf C; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
  • Bouhelal R; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
  • Koziczak-Holbro M; Musculoskeletal, NIBR, Basel, Switzerland.
  • Amati AM; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
  • Techer-Etienne V; Department of Chemistry & Biochemistry, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland.
  • Flotte L; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
  • Reymann N; Musculoskeletal, NIBR, Basel, Switzerland.
  • Kapur K; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
  • Hoersch S; NIBR Informatics, NIBR, Basel, Switzerland.
  • Oakeley EJ; NIBR Informatics, NIBR, Basel, Switzerland.
  • Schuffenhauer A; ASI, NIBR, Basel, Switzerland.
  • Gubler H; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Basel, 4056, Switzerland.
  • Lounkine E; NIBR Informatics, NIBR, Basel, Switzerland.
  • Farmer P; Chemical Biology & Therapeutics, NIBR, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Sci Rep ; 10(1): 9670, 2020 06 15.
Article em En | MEDLINE | ID: mdl-32541899
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Agonistas Adrenérgicos beta / Perfilação da Expressão Gênica / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Agonistas Adrenérgicos beta / Perfilação da Expressão Gênica / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article