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Irregularly Bridged Epipolythiodioxopiperazines and Related Analogues: Sources, Structures, and Biological Activities.
Zhu, Meilin; Zhang, Xuewen; Huang, Xuenan; Wang, Haotian; Anjum, Komal; Gu, Qianqun; Zhu, Tianjiao; Zhang, Guojian; Li, Dehai.
Afiliação
  • Zhu M; School of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, Anhui, People's Republic of China.
  • Zhang X; School of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, Anhui, People's Republic of China.
  • Huang X; School of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, Anhui, People's Republic of China.
  • Wang H; School of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, Anhui, People's Republic of China.
  • Anjum K; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Gu Q; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Zhu T; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Zhang G; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, People's Republic of China.
  • Li D; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
J Nat Prod ; 83(6): 2045-2053, 2020 06 26.
Article em En | MEDLINE | ID: mdl-32543845
Epipolythiodioxopiperazines (ETPs) are a class of biologically active fungal secondary metabolites characterized by a bridged polysulfide piperazine ring. Regularly, the sulfide functionality is attached in the α-positions of the dioxopiperazine scaffold. However, ETPs possessing irregular sulfur bridges have rarely been explored. This review summarizes that 83 compounds of this subtype have been isolated and characterized since the discovery of gliovirin in 1982. Herein, particular emphasis is given to the isolation, chemistry, and biological activity of this subtype. For a better understanding, a relevant summary focusing on the source microorganisms and their taxonomy is provided and will help elucidate the fascinating chemistry and biology of these unusual ETPs.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperazinas / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article