NOVEL antioxidant and oxidant biomarkers related to sarcopenia in COPD.
Heart Lung
; 50(1): 184-191, 2021.
Article
em En
| MEDLINE
| ID: mdl-32546379
ABSTRACT
BACKGROUND:
The relation between oxidative stress (OS) and sarcopenia in COPD remains unknown.OBJECTIVE:
To analyze OS levels and its association with sarcopenia in COPD.METHODS:
Thirty-nine individuals with COPD (69±7years; 41%female) and thirty-five for the control group (69±7years; 43%female) were included. Advanced oxidation protein products (AOPP), paraoxonase-1 (PON1), superoxide dismutase activity (SOD), catalase dismutase activity (CAT), sulfhydryl group (SH), nitric oxide metabolites (NOX), total radical trapping antioxidant parameter (TRAP) were analysed. OS markers were correlated with handgrip and quadriceps strength, gait speed, skeletal muscle mass index, fat-free mass index, maximum inspiratory and expiratory pressure. European criteria were used to identify sarcopenia.RESULTS:
In COPD, antioxidant capacity was correlated with muscle mass and strength (r from 0.5 to 0.64) P<0.05 for all. TRAP≤ 850 µM/trolox and AOPP≤65 µM/l were associated with sarcopenia (OR8.3; 95% CI 1.4-49.6 and OR14; 95%CI 2.2-87.1, respectively; P<0.05 for both).CONCLUSION:
OS is associated with sarcopenia in COPD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença Pulmonar Obstrutiva Crônica
/
Sarcopenia
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article