Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.
BMC Neurol
; 20(1): 248, 2020 Jun 18.
Article
em En
| MEDLINE
| ID: mdl-32552792
ABSTRACT
BACKGROUND:
COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. CASE PRESENTATION We describe a 78-year old immunocompromised woman who presented with altered mental status after witnessed seizure-like activity at home. She was found to have SARS-CoV-2 infection and associated neuroinflammation. In this case, we undertake the first detailed analysis of cerebrospinal fluid (CSF) cytokines during COVID-19 infection and find a unique pattern of inflammation in CSF, but no evidence of viral neuroinvasion.CONCLUSION:
Our findings suggest that neurologic symptoms such as encephalopathy and seizures may be the initial presentation of COVID-19. Central nervous system inflammation may associate with neurologic manifestations of disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
/
Citocinas
/
Infecções por Coronavirus
/
Encefalite Viral
/
Pandemias
/
Betacoronavirus
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article