Changes in Physical Activity and Sedentary Patterns on Cardiometabolic Outcomes in the Transition to Adolescence: International Children's Accelerometry Database 2.0.

OBJECTIVE: To examine the associations of changes in physical activity and sedentary patterns with changes in cardiometabolic outcomes from childhood to adolescence. STUDY DESIGN: Youth from the International Children's Accelerometry Database (n = 1088; 55% girls), aged 8-13 years and followed for ∼4 years, were used in this analysis. Hip-mounted accelerometers were used and all physical activity intensities were expressed as the % of total wear-time. Sedentary time was separated into time spent in bouts <10 minutes and ≥10 minutes. A composite z score for cardiometabolic risk (CMR score) was computed by summing the standardized values for systolic and diastolic blood pressure, triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and the inverse high-density lipoprotein cholesterol. Multivariate analyses were performed using adjusted linear regression models. RESULTS: Increase in sedentary time was unfavorably associated with changes in CMR score (ß = 0.021; CI 0.004-0.037), TG (ß = 0.003; CI 0.001-0.005), and diastolic blood pressure (ß = 0.068; CI 0.009-0.128). Decrease in moderate-to-vigorous physical activity was unfavorably associated with changes in LDL-c (ß = -0.009; CI -0.017 to -0.001) and TG (ß = -0.007; CI -0.013 to -0.001). Increase in ≥10 minutes sedentary time was unfavorably associated with changes in CMR score (ß = 0.017; CI 0.004-0.030), LDL-c (ß = 0.003; CI 0.000-0.005), and TG (ß = 0.003; CI 0.000-0.004). Decrease in light-intensity physical activity was unfavorably associated with changes in CMR score (ß = -0.020; CI = -0.040 to 0.000). CONCLUSIONS: More physical activity and less prolonged sedentary time are beneficial for cardiometabolic health in youth transitioning to adolescence.