Insulin autoimmune syndrome.
Endocrinol Diabetes Metab Case Rep
; 20202020 Jun 04.
Article
em En
| MEDLINE
| ID: mdl-32554828
ABSTRACT
SUMMARY:
Insulin autoimmune syndrome (Hirata's disease) is a disorder caused by development of autoantibodies to insulin and manifested by hypoglycaemic syndrome. The overwhelming majority of physicians do not include it in the differential diagnosis of hypoglycaemic states because of a misconception of an extremely low prevalence of this condition. This results in unnecessary drug therapy and unjustified surgical interventions in patients that otherwise would be successfully treated conservatively. This disease is strongly associated with certain alleles of the HLA gene. In most cases, this condition develops in predisposed individuals taking drugs containing sulfhydryl groups. Formation of autoantibodies to insulin may be observed in patients with other autoimmune disorders, as well as in those with multiple myeloma or monoclonal gammopathy of undetermined significance. This paper presents the first Russian case report of insulin autoimmune syndrome in an adult patient. LEARNING POINTS Insulin autoimmune syndrome, Hirata's disease, anti-insulin antibodies, and hypoglycaemia.
2020; Adult; Albumin; Anti-insulin antibodies; Anxiety; C-peptide (blood); Diabetes; Dizziness; Exercise tolerance; Female; Glucose (blood); Glucose (blood, fasting); Glucose (blood, postprandial); Glucose tolerance (oral); HLA genotyping; HOMA; Hypoglycaemia; Immunoglobulin A; Insulin; Insulin (fasting); Insulin autoimmune syndrome; June; New disease or syndrome: presentations/diagnosis/management; Pancreas; Proinsulin; Protein electrophoresis; Russian Federation; Thioctic acid*; Thyroid ultrasonography; Urinalysis; White; alpha-lipoic acid*
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article