Utilising animal models to evaluate oseltamivir efficacy against influenza A and B viruses with reduced in vitro susceptibility.

Farrukee, Rubaiyea; Tai, Celeste Ming-Kay; Oh, Ding Yuan; Anderson, Danielle E; Gunalan, Vithiagaran; Hibberd, Martin; Lau, Gary Yuk-Fai; Barr, Ian G; Messling, Veronika von; Maurer-Stroh, Sebastian; Hurt, Aeron C

Utilising animal models to evaluate oseltamivir efficacy against influenza A and B viruses with reduced in vitro susceptibility.

Farrukee, Rubaiyea; Tai, Celeste Ming-Kay; Oh, Ding Yuan; Anderson, Danielle E; Gunalan, Vithiagaran; Hibberd, Martin; Lau, Gary Yuk-Fai; Barr, Ian G; Messling, Veronika von; Maurer-Stroh, Sebastian; Hurt, Aeron C.

Afiliação

Farrukee R; WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Tai CM; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Oh DY; WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Anderson DE; WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Gunalan V; School of Health and Life Sciences, Federation University, Churchill, Victoria, Australia.
Hibberd M; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
Lau GY; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore.
Barr IG; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Messling VV; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
Maurer-Stroh S; WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Hurt AC; Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.

PLoS Pathog ; 16(6): e1008592, 2020 06.

Article em En | MEDLINE | ID: mdl-32555740

Assuntos

Vírus da Influenza A Subtipo H1N1; Vírus da Influenza A Subtipo H3N2; Vírus da Influenza B; Infecções por Orthomyxoviridae; Oseltamivir; Animais; Feminino; Masculino; Substituição de Aminoácidos; Modelos Animais de Doenças; Avaliação Pré-Clínica de Medicamentos; Furões; Vírus da Influenza A Subtipo H1N1/genética; Vírus da Influenza A Subtipo H1N1/metabolismo; Vírus da Influenza A Subtipo H3N2/genética; Vírus da Influenza A Subtipo H3N2/metabolismo; Vírus da Influenza B/genética; Vírus da Influenza B/metabolismo; Macaca fascicularis; Macrolídeos; Mutação de Sentido Incorreto; Neuraminidase/genética; Neuraminidase/metabolismo; Infecções por Orthomyxoviridae/tratamento farmacológico; Infecções por Orthomyxoviridae/genética; Infecções por Orthomyxoviridae/metabolismo; Infecções por Orthomyxoviridae/patologia; Oseltamivir/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza B / Infecções por Orthomyxoviridae / Vírus da Influenza A Subtipo H1N1 / Vírus da Influenza A Subtipo H3N2 / Oseltamivir Tipo de estudo: Guideline / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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