Your browser doesn't support javascript.
loading
DC-STAMP and TACE Levels are Higher in Patients with Periodontitis.
Guardiola, Cyro José de Almeida; Clemente-Napimoga, Juliana Trindade; Martinez, Elizabeth Ferreira; Abdalla, Henrique Balassini; Peruzzo, Daiane Cristina; Joly, Júlio César; Napimoga, Marcelo Henrique.
Afiliação
  • Guardiola CJA; Periodontics and Implantology, Instituto de Pesquisas São Leopoldo Mandic, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.
  • Clemente-Napimoga JT; Laboratory of Neuroimmune Interface of Pain Research Instituto de Pesquisas São Leopoldo Mandic, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.
  • Martinez EF; Periodontics and Implantology, Instituto de Pesquisas São Leopoldo Mandic, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.
  • Abdalla HB; Laboratory of Neuroimmune Interface of Pain Research Instituto de Pesquisas São Leopoldo Mandic, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.
  • Peruzzo DC; Periodontics and Implantology, Instituto de Pesquisas São Leopoldo Mandic, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.
  • Joly JC; Periodontics and Implantology, Instituto de Pesquisas São Leopoldo Mandic, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.
  • Napimoga MH; Laboratory of Neuroimmune Interface of Pain Research Instituto de Pesquisas São Leopoldo Mandic, Faculdade São Leopoldo Mandic, Campinas, SP, Brazil.
Braz Dent J ; 31(2): 122-126, 2020.
Article em En | MEDLINE | ID: mdl-32556010
ABSTRACT
Although periodontitis is one of the commonest infectious inflammatory diseases in humans, the mechanisms involved with its immunopathology remain ill understood. Numerous molecules may induce inflammation and lead to bone resorption, secondary to activation of monocytes into osteoclasts. TACE (TNF-α converting enzyme) and DC-STAMP (dendritic cell-specific transmembrane protein) appear to play a role on bone resorption since TACE induces the release of sRANKL (soluble receptor activator of nuclear factor kappa-ß ligand) whereas DC-STAMP is a key factor in osteoclast induction. The present study evaluated the levels of TACE and DC-STAMP in patients with and without periodontitis. Twenty individuals were selected 10 periodontally healthy participants undergoing gingivectomy for esthetic reasons and 10 diagnosed with periodontitis. Protein levels of such molecules in gingival tissue were established using Western blotting. Protein levels of both TACE and DC-STAMP were higher in the periodontitis group than in the control group (p<0.05; Student t-test). In conclusion, TACE and DC-STAMP protein levels are elevated in patients with periodontitis, favoring progression of bone resorption.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Reabsorção Óssea / Proteínas Adaptadoras de Transdução de Sinal / Proteína ADAM17 / Proteínas de Membrana Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Periodontite / Reabsorção Óssea / Proteínas Adaptadoras de Transdução de Sinal / Proteína ADAM17 / Proteínas de Membrana Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article