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Neuromelanin imaging analyses of the substantia nigra in patients with Machado-Joseph disease.
Nakata, Yasuhiro; Sakamoto, Atsuko; Kawata, Akihiro.
Afiliação
  • Nakata Y; Department of Neuroradiology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan. nakatay-tky@umin.ac.jp.
  • Sakamoto A; Department of Neuroradiology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
  • Kawata A; Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
Neuroradiology ; 62(11): 1433-1439, 2020 Nov.
Article em En | MEDLINE | ID: mdl-32556403
PURPOSE: Machado-Joseph disease (MJD/SCA3) is the most frequent spinocerebellar ataxia worldwide. Pathological studies revealed less melanin-containing dopaminergic neurons in the substantia nigra (SN) pars compacta in MJD/SCA3 patients. The purpose of this study was to quantify the damage in the SN reported for MJD/SCA3 patients in vivo using neuromelanin MR imaging. METHODS: We retrospectively reviewed the clinical information and MR imaging in sixteen MJD/SCA3 patients and fourteen healthy controls. High-resolution T1-WI of the SN were acquired using a 3-T MR system. The neuromelanin-related contrast (NRC), which was defined as the number of pixels of high-signal-intensity areas on T1-WI in the SN, was calculated semi-automatically. The NRC values were compared between MJD/SCA3 patients and normal controls. RESULTS: The NRC values were significantly lower in MJD/SCA3 patients than in healthy controls. In MJD/SCA3 patients, a significant negative correlation existed between disease durations and NRC values. No significant difference in the NRC values was revealed between the MJD/SCA3 patients with and without parkinsonism. CONCLUSION: Neuromelanin in the SN may decrease at the early stage of the disease and continue to decrease over time with the disease duration in MJD/SCA3 patients. The NRC may be a useful biological index for monitoring MJD/SCA3.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Substância Negra / Imageamento por Ressonância Magnética / Doença de Machado-Joseph / Melaninas Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Substância Negra / Imageamento por Ressonância Magnética / Doença de Machado-Joseph / Melaninas Tipo de estudo: Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article