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Role of Adenosine in Epilepsy and Seizures.
Tescarollo, Fabio C; Rombo, Diogo M; DeLiberto, Lindsay K; Fedele, Denise E; Alharfoush, Enmar; Tomé, Ângelo R; Cunha, Rodrigo A; Sebastião, Ana M; Boison, Detlev.
Afiliação
  • Tescarollo FC; Deptartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
  • Rombo DM; Faculty of Medicine, Institute of Pharmacology and Neurosciences, Lisbon, Portugal.
  • DeLiberto LK; Institute of Molecular Medicine, University of Lisbon, Lisbon, Portugal.
  • Fedele DE; Deptartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
  • Alharfoush E; Deptartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
  • Tomé ÂR; Deptartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.
  • Cunha RA; Faculty of Science and Technology, Department of Life Sciences, University of Coimbra, Coimbra, Portugal.
  • Sebastião AM; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
  • Boison D; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
J Caffeine Adenosine Res ; 10(2): 45-60, 2020 Jun 01.
Article em En | MEDLINE | ID: mdl-32566903
ABSTRACT
Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure activity produces large quantities of adenosine, and it is this seizure-induced adenosine surge that normally stops a seizure. However, within the context of epilepsy, adenosine plays a wide spectrum of different roles. It not only controls seizures (ictogenesis), but also plays a major role in processes that turn a normal brain into an epileptic brain (epileptogenesis). It is involved in the control of abnormal synaptic plasticity and neurodegeneration and plays a major role in the expression of comorbid symptoms and complications of epilepsy, such as sudden unexpected death in epilepsy (SUDEP). Given the important role of adenosine in epilepsy, therapeutic strategies are in development with the goal to utilize adenosine augmentation not only for the suppression of seizures but also for disease modification and epilepsy prevention, as well as strategies to block adenosine A2A receptor overfunction associated with neurodegeneration. This review provides a comprehensive overview of the role of adenosine in epilepsy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article