<i>CYP3A5</i> Genotype as a Potential Pharmacodynamic Biomarker for Tacrolimus Therapy in Ulcerative Colitis in Japanese Patients.

Yamamoto, Yuki; Nakase, Hiroshi; Matsuura, Minoru; Maruyama, Shihoko; Masuda, Satohiro

CYP3A5 Genotype as a Potential Pharmacodynamic Biomarker for Tacrolimus Therapy in Ulcerative Colitis in Japanese Patients.

Yamamoto, Yuki; Nakase, Hiroshi; Matsuura, Minoru; Maruyama, Shihoko; Masuda, Satohiro.

Afiliação

Yamamoto Y; Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Nakase H; Department of Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Matsuura M; Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Minami 1-jo Nishi 17-chome, Chuo-ku, Sapporo, Hokkaido 060-8556, Japan.
Maruyama S; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Masuda S; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

Int J Mol Sci ; 21(12)2020 Jun 18.

Article em En | MEDLINE | ID: mdl-32570960

Assuntos

Colite Ulcerativa/tratamento farmacológico; Citocromo P-450 CYP3A/genética; Imunossupressores/administração & dosagem; Tacrolimo/administração & dosagem; Subfamília B de Transportador de Cassetes de Ligação de ATP/genética; Adulto; Idoso; Estudos de Casos e Controles; Colite Ulcerativa/genética; Feminino; Regulação da Expressão Gênica; Genótipo; Humanos; Imunossupressores/farmacocinética; Japão; Masculino; Pessoa de Meia-Idade; Variantes Farmacogenômicos; Tacrolimo/farmacocinética

Palavras-chave

clinical activity index; inflammatory bowel disease; mucosal concentration; multidrug resistance 1; polymorphism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / Tacrolimo / Citocromo P-450 CYP3A / Imunossupressores Tipo de estudo: Observational_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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