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Triptolide impairs genome integrity by directly blocking the enzymatic activity of DNA-PKcs in human cells.
Cai, Bailian; Hu, Zhiyi; Tang, Huanyin; Hu, Zhangsen; Mao, Zhiyong; Liu, Binya; Xu, Xiaojun; Jiang, Ying; Wan, Xiaoping.
Afiliação
  • Cai B; Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
  • Hu Z; Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
  • Tang H; Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Hu Z; Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Mao Z; Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China; Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Resea
  • Liu B; Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
  • Xu X; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 210009, China. Electronic address: xiaojunxu2000@163.com.
  • Jiang Y; Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. Electronic address: ying_jiang@tongji.edu.cn.
  • Wan X; Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China; Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Resea
Biomed Pharmacother ; 129: 110427, 2020 Sep.
Article em En | MEDLINE | ID: mdl-32574974
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenantrenos / Instabilidade Genômica / Inibidores de Proteínas Quinases / Diterpenos / Proteína Quinase Ativada por DNA / Quebras de DNA de Cadeia Dupla / Reparo do DNA por Junção de Extremidades / Fibroblastos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenantrenos / Instabilidade Genômica / Inibidores de Proteínas Quinases / Diterpenos / Proteína Quinase Ativada por DNA / Quebras de DNA de Cadeia Dupla / Reparo do DNA por Junção de Extremidades / Fibroblastos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article