Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes.

Inoue, Chisato; Sobue, Sayaka; Mizutani, Naoki; Kawamoto, Yoshiyuki; Nishizawa, Yuji; Ichihara, Masatoshi; Takeuchi, Toshiyuki; Hayakawa, Fumihiko; Suzuki, Motoshi; Ito, Tetsuro; Nozawa, Yoshinori; Murate, Takashi

Inoue, Chisato; Sobue, Sayaka; Mizutani, Naoki; Kawamoto, Yoshiyuki; Nishizawa, Yuji; Ichihara, Masatoshi; Takeuchi, Toshiyuki; Hayakawa, Fumihiko; Suzuki, Motoshi; Ito, Tetsuro; Nozawa, Yoshinori; Murate, Takashi.

Afiliação

Inoue C; College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Sobue S; College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Mizutani N; College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Kawamoto Y; College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Nishizawa Y; College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Ichihara M; College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Takeuchi T; Department of Molecular Oncology, Fujita Health University, Toyoake, Japan.
Hayakawa F; Department of Medical Technology, Nagoya University Graduate School of Health Sciences, Nagoya, Japan.
Suzuki M; Department of Molecular Oncology, Fujita Health University, Toyoake, Japan.
Ito T; Gifu Pharmaceutical University, Gifu, Japan.
Nozawa Y; Gifu Prefectural Research Institute for Health and Environmental Sciences, Kakamigahara, Japan.
Murate T; Tokai Gakuin University, Kakamigahara, Japan.

Nagoya J Med Sci ; 82(2): 261-280, 2020 May.

Article em En | MEDLINE | ID: mdl-32581406

Assuntos

Antioxidantes/farmacologia; Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Glucosiltransferases/efeitos dos fármacos; Fosfotransferases (Aceptor do Grupo Álcool)/efeitos dos fármacos; Resveratrol/farmacologia; Estilbenos/farmacologia; Clorometilcetonas de Aminoácidos/farmacologia; Inibidores de Caspase/farmacologia; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Resistencia a Medicamentos Antineoplásicos; Glucosiltransferases/antagonistas & inibidores; Glucosiltransferases/metabolismo; Humanos; Concentração Inibidora 50; Células Jurkat; Células K562; Células PC-3; Fosfotransferases (Aceptor do Grupo Álcool)/antagonistas & inibidores; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo; Células U937

Palavras-chave

GCS; SPHK; apoptosis; sphingolipid rheostat; vaticanol C

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estilbenos / Apoptose / Fosfotransferases (Aceptor do Grupo Álcool) / Proliferação de Células / Resveratrol / Glucosiltransferases / Antioxidantes Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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