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2-Hydroxy-4-methoxybenzaldehyde from Hemidesmus indicus is antagonistic to Staphylococcus epidermidis biofilm formation.
Kannappan, Arunachalam; Durgadevi, Ravindran; Srinivasan, Ramanathan; Lagoa, Ricardo José Lucas; Packiavathy, Issac Abraham Sybiya Vasantha; Pandian, Shunmugiah Karutha; Veera Ravi, Arumugam.
Afiliação
  • Kannappan A; Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Durgadevi R; Department of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, PR China.
  • Srinivasan R; Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Lagoa RJL; Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Packiavathy IASV; Fujian Provincial Key Laboratory of Agroecological Processing and Safety Monitoring, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, PR China.
  • Pandian SK; Key Laboratory of Crop Ecology and Molecular Physiology (Fujian Agriculture and Forestry University), Fujian Province University, Fuzhou, PR China.
  • Veera Ravi A; School of Technology and Management, Polytechnic Institute of Leiria, Leiria, Portugal.
Biofouling ; 36(5): 549-563, 2020 05.
Article em En | MEDLINE | ID: mdl-32586125
Staphylococcus epidermidis (SE) is an opportunistic nosocomial pathogen that accounts for recalcitrant device-related infections worldwide. Owing to the growing interest in plants and their secondary metabolites targeting bacterial adhesion, this study was intended to uncover the anti-biofilm potential of Hemidesmus indicus and its major constituent 2-hydroxy-4-methoxybenzaldehyde (HMB) against SE. The minimum biofilm inhibitory concentration (MBIC) of H. indicus root extract and HMB were found to be 500 and 250 µg ml-1, respectively. The results of time-dependent biofilm inhibition and mature biofilm disruption assays confirmed that HMB targets initial cell adhesion. Furthermore, interference by HMB in the expression of adhesin genes (icaA, aap and bhp) and biofilm components was associated with an increased susceptibility of SE to oxidative stress and antibiotics. To conclude, this study reports for the first time HMB as a potential drug against SE biofilms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus epidermidis / Benzaldeídos / Biofilmes / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus epidermidis / Benzaldeídos / Biofilmes / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article