High-speed atomic force microscopy directly visualizes conformational dynamics of the HIV Vif protein in complex with three host proteins.

Pan, Yangang; Shlyakhtenko, Luda S; Lyubchenko, Yuri L

Pan, Yangang; Shlyakhtenko, Luda S; Lyubchenko, Yuri L.

Afiliação

Pan Y; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Shlyakhtenko LS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Lyubchenko YL; Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska, USA. Electronic address: ylyubchenko@unmc.edu.

J Biol Chem ; 295(34): 11995-12001, 2020 08 21.

Article em En | MEDLINE | ID: mdl-32587092

Assuntos

HIV-1/química; Microscopia de Força Atômica; Complexos Multiproteicos/química; Complexos Multiproteicos/ultraestrutura; Produtos do Gene vif do Vírus da Imunodeficiência Humana/química; HIV-1/metabolismo; Humanos; Complexos Multiproteicos/metabolismo; Produtos do Gene vif do Vírus da Imunodeficiência Humana/metabolismo

Palavras-chave

Elongin-BCBF-ß complex (VCBC); VifElongin-C; acquired immune deficiency syndrome (AIDS); double-stranded DNA (dsDNA); high-speed atomic force microscopy (HS-AFM); human APOBEC3 family of cytidine deaminase (APOBEC3) proteins; human immunodeficiency virus (HIV); protein assembly; protein conformation; protein dynamic; proteinDNA interaction; single-stranded DNA (ssDNA); virus infectivity factor (Vif)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: HIV-1 / Microscopia de Força Atômica / Complexos Multiproteicos / Produtos do Gene vif do Vírus da Imunodeficiência Humana Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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