[The inhibitors of the apical sodium-dependent bile acid transporter (ASBT) as promising drugs]. / Ingibitory natrii-zavisimogo perenoschika zhelchnykh kislot (ASBT) kak perspektivnye lekarstvennye sredstva.
Biomed Khim
; 66(3): 185-195, 2020 May.
Article
em Ru
| MEDLINE
| ID: mdl-32588824
ABSTRACT
Inhibition of the apical sodium-dependent bile acid transporter (ASBT, also known as IBAT - ileal bile acid transporter, SLC10A2) leads to disruption of the enterohepatic circulation of bile acids and their excretion with fecal masses. This is accompanied by cholesterol utilization for synthesis of new bile acids. ASBT inhibitors are promising drugs for the treatment of such diseases as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, type 2 diabetes mellitus, necrotic enterocolitis, chronic constipation, atherosclerosis. To date the most known chemically synthesized inhibitors are A3309, SHP626, A4250, 264W94, GSK2330672, SC-435. All of them are at different stages of clinical trials, which confirm the high efficacy and good tolerance of these inhibitors. Current trends in this field also include directed chemical synthesis of ASBT inhibitors, as well as their search among substances of plant origin.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transportadores de Ânions Orgânicos Dependentes de Sódio
/
Simportadores
/
Diabetes Mellitus Tipo 2
Limite:
Humans
Idioma:
Ru
Ano de publicação:
2020
Tipo de documento:
Article