A randomized controlled trial of amyloid positron emission tomography results disclosure in mild cognitive impairment.
Alzheimers Dement
; 16(9): 1330-1337, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-32588971
ABSTRACT
INTRODUCTION:
Recent studies suggest that Alzheimer's disease (AD) biomarker disclosure has no discernable psychological impact on cognitively healthy persons. Far less is known about how such results affect symptomatic individuals and their caregivers.METHODS:
Randomized controlled trial of 82 mild cognitive impairment (MCI) patient and caregiver dyads (total n = 164) to determine the effect of receiving amyloid positron emission tomography results on understanding of, and perceived efficacy to cope with, MCI over 52 weeks of follow-up.RESULTS:
Gains in the primary outcomes were not consistently observed. Amyloid negative patients reported greater perceived ambiguity regarding MCI at follow-up, while moderate and sustained emotional distress was observed in patients, and to a lesser extent, caregivers, of those who were amyloid positive. There was no corresponding increase in depressive symptoms.DISCUSSION:
These findings point to the possibility that both MCI patients and caregivers may need emotional support after the disclosure of amyloid scan results.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Revelação
/
Tomografia por Emissão de Pósitrons
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Disfunção Cognitiva
/
Amiloide
Tipo de estudo:
Clinical_trials
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article