Integration of genomics, metagenomics, and metabolomics to identify interplay between susceptibility alleles and microbiota in adenoma initiation.

Moskowitz, Jacob E; Doran, Anthony G; Lei, Zhentian; Busi, Susheel B; Hart, Marcia L; Franklin, Craig L; Sumner, Lloyd W; Keane, Thomas M; Amos-Landgraf, James M

Moskowitz, Jacob E; Doran, Anthony G; Lei, Zhentian; Busi, Susheel B; Hart, Marcia L; Franklin, Craig L; Sumner, Lloyd W; Keane, Thomas M; Amos-Landgraf, James M.

Afiliação

Moskowitz JE; Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, 65201, USA.
Doran AG; Present Address: F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Lei Z; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.
Busi SB; European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
Hart ML; Department of Biochemistry, MU Metabolomics Center, University of Missouri Bond Life Sciences Center, Columbia, MO, 65201, USA.
Franklin CL; Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, 65201, USA.
Sumner LW; Mutant Mouse Resource and Research Center, University of Missouri, 4011 Discovery Drive, Columbia, MO, 65201, USA.
Keane TM; Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, 65201, USA.
Amos-Landgraf JM; Mutant Mouse Resource and Research Center, University of Missouri, 4011 Discovery Drive, Columbia, MO, 65201, USA.

BMC Cancer ; 20(1): 600, 2020 Jun 29.

Article em En | MEDLINE | ID: mdl-32600361

Assuntos

Adenoma/genética; Neoplasias Colorretais/genética; Microbioma Gastrointestinal/fisiologia; Predisposição Genética para Doença; Adenoma/metabolismo; Adenoma/microbiologia; Proteína da Polipose Adenomatosa do Colo/genética; Alelos; Animais; Neoplasias Colorretais/metabolismo; Neoplasias Colorretais/microbiologia; Modelos Animais de Doenças; Feminino; Humanos; Masculino; Metabolômica; Metagenômica; Camundongos; Mutação

Palavras-chave

Apc; Colorectal cancer; Genetics; Gut microbiota; Metabolomics; Min

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Adenoma / Predisposição Genética para Doença / Microbioma Gastrointestinal Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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