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Effect of ultrasonic micro-arc oxidation on the antibacterial properties and cell biocompatibility of Ti-Cu alloy for biomedical application.
Hu, Jiali; Li, Haixia; Wang, Xiaoyan; Yang, Lei; Chen, Mian; Wang, Renxian; Qin, Gaowu; Chen, Da-Fu; Zhang, Erlin.
Afiliação
  • Hu J; School of Materials Science and Engineering, Key Lab. for Anisotropy and Texture of Materials, Education Ministry of China, Northeastern University, Shenyang 110819, China.
  • Li H; School of Materials Science and Engineering, Key Lab. for Anisotropy and Texture of Materials, Education Ministry of China, Northeastern University, Shenyang 110819, China.
  • Wang X; School of Metallurgy, Northeastern University, Shenyang 110819, China.
  • Yang L; School of Materials Science and Engineering, Key Lab. for Anisotropy and Texture of Materials, Education Ministry of China, Northeastern University, Shenyang 110819, China; Research Center for Metallic Wires, Northeastern University, Shenyang 110819, China.
  • Chen M; School of Materials Science and Engineering, Key Lab. for Anisotropy and Texture of Materials, Education Ministry of China, Northeastern University, Shenyang 110819, China.
  • Wang R; Laboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, Beijing Research Institute of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Beijing 100035, China.
  • Qin G; School of Materials Science and Engineering, Key Lab. for Anisotropy and Texture of Materials, Education Ministry of China, Northeastern University, Shenyang 110819, China; Research Center for Metallic Wires, Northeastern University, Shenyang 110819, China.
  • Chen DF; Laboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, Beijing Research Institute of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Beijing 100035, China. Electronic address: chendafu@jsthospital.org.
  • Zhang E; School of Materials Science and Engineering, Key Lab. for Anisotropy and Texture of Materials, Education Ministry of China, Northeastern University, Shenyang 110819, China; Research Center for Metallic Wires, Northeastern University, Shenyang 110819, China. Electronic address: zhangel@atm.neu.edu.cn
Mater Sci Eng C Mater Biol Appl ; 115: 110921, 2020 Oct.
Article em En | MEDLINE | ID: mdl-32600677
ABSTRACT
In order to improve antibacterial properties and cell biocompatibility of Ti-Cu alloy, an ultrasonic micro-arc oxidation (UMAO) has been applied to Ti-Cu alloy. The corrosion resistance, antibacterial activity and cell compatibility of Ti-Cu alloy before and after UMAO were studied in detail by means of electrochemical test, plate count method and CCK-8 test scanning electron microscopy (SEM) technology to evaluate the application possibilities of UMAO as a surface bio-modification method for Ti-Cu alloy. The surface microstructure characterisation showed that a typical porous coating with a pore diameter of 3-8 µm and a thickness of 5-15 µm was formed on the surface of the Ti-Cu alloy, which significantly improved the surface roughness and hydrophilicity. The plate count method demonstrated that UMAO coatings on Ti-Cu alloy showed strong antibacterial activity (≥99%) against Staphylococcus aureus (S. aureus) even after being immersed in a physiological saline for up to 20 days, indicating that UMAO-treated Ti-Cu alloy had very strong long-term antibacterial properties. It is believed that the strong long-term antimicrobial properties of Ti-Cu-UMAO samples were mainly due to the formation of Cu2O and CuO in UMAO coatings. The results of cell compatibility evaluation showed that UMAO treatment did not bring about cytotoxicity but improved the early adhesion of MC3T3 cell.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Materiais Biocompatíveis / Ligas / Antibacterianos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Materiais Biocompatíveis / Ligas / Antibacterianos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article