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Poly(ADP-ribose) Glycohydrolase Inhibition Sequesters NAD+ to Potentiate the Metabolic Lethality of Alkylating Chemotherapy in IDH-Mutant Tumor Cells.
Nagashima, Hiroaki; Lee, Christine K; Tateishi, Kensuke; Higuchi, Fumi; Subramanian, Megha; Rafferty, Seamus; Melamed, Lisa; Miller, Julie J; Wakimoto, Hiroaki; Cahill, Daniel P.
Afiliação
  • Nagashima H; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Lee CK; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Tateishi K; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Higuchi F; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Subramanian M; Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  • Rafferty S; Department of Neurosurgery, Dokkyo Medical University, Mibu, Tochigi, Japan.
  • Melamed L; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Miller JJ; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Wakimoto H; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
  • Cahill DP; Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. cahill@mgh.harvard.edu hwakimoto@mgh.harvard.edu julie.miller@mgh.harvard.edu.
Cancer Discov ; 10(11): 1672-1689, 2020 11.
Article em En | MEDLINE | ID: mdl-32606138
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antineoplásicos Alquilantes / Glicosídeo Hidrolases / NAD Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antineoplásicos Alquilantes / Glicosídeo Hidrolases / NAD Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article