Influence of border-age on survival of sporadic renal cell carcinoma: young adults versus octogenarians.
Int Urol Nephrol
; 52(11): 2087-2095, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32607959
ABSTRACT
PURPOSE:
To compare the effects of two border-age groups young adults and octogenarians on survival of sporadic renal cell carcinoma (RCC).METHODS:
We reviewed the records of 1619 patients that underwent radical or partial nephrectomy due to RCC between January 2004 and December 2018 in two high-volume centers. Patients were divided into two groups based on their age ≤ 40 years old (group 1) and ≥ 80 years old (group 2). We analyzed the demographic, clinical and histological features of the groups and performed univariable and multivariable Cox regression analyses to evaluate predictors associated with survival.RESULTS:
Median ages of patients were 35.5 years and 82 years in group 1 (n = 90) and group 2 (n = 55), respectively. Radical nephrectomy rate was statistically higher in group 2 (p = 0.004). Median follow-up was 72 (11-192) months in group 1 and 30 months (5-103) in group 2 (p < 0.001). The 5-year (90.2% vs. 80.2%) and 8-year (84.8% vs. 60.2%) overall survivals (OS) of the groups were statistically different (p < 0.001). Patients in group 1 demonstrated a 5 and 10-year cancer-specific survival (CSS) of 90.2% and 84.7%, whereas these rates were 82.4% and 54.9% for group 2 (p < 0.05). We found that higher hemoglobin drop (HR 1.497), presence of sarcomatoid differentiation (HR 4.307), high-stage disease (HR 2.704), and metastasis detected in the follow-up (HR 12.805) were independent risk factors that shortened OS (p < 0.05).CONCLUSION:
Sporadic RCC was associated with a more favorable CSS and OS in young adults compared to the octogenarians. Although two border-age groups had similar pathologies, they have different prognosis and survival rates.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
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Neoplasias Renais
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Nefrectomia
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged80
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article