Syntheses of C2'-Fluorinated Analogs of Solamin.
Chem Pharm Bull (Tokyo)
; 68(7): 675-678, 2020.
Article
em En
| MEDLINE
| ID: mdl-32612003
ABSTRACT
The details of the total syntheses of C2'-fluorinated analogs of solamin, an antitumor annonaceous acetogenin, are described. Fluorine was enantioselectively introduced at the C2'-position by organocatalytic α-fluorination of the aldehyde according to a previously reported method. C2'-fluorinated solamin and its C2'-diastereomer were synthesized by the Sonogashira coupling of a tetrahydrofuran fragment and fluorine-containing γ-lactone fragments.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzetônio
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article