Circulating omentin-1 levels and inflammation in polycystic ovary syndrome.
Ginekol Pol
; 91(6): 308-312, 2020.
Article
em En
| MEDLINE
| ID: mdl-32627151
ABSTRACT
OBJECTIVES:
The aim of the study was to analyze interrelation between plasma omentin-1 levels and nutritional status and inflammation in PCOS. MATERIAL ANDMETHODS:
A cross-sectional study involving 86 PCOS (47 obese) and 72 Non-PCOS women (41 obese) determined anthropometric parameters and body composition. Serum glucose, insulin and omentin-1, TNF-α, sTNFRs, IL-6 and sR-IL6 were measured in the fasting state.RESULTS:
Plasma omentin-1 levels were significantly lower in the PCOS than in the Non-PCOS group and both corresponding normal weight and obese subgroups. In three analyzed least-angle regression (LARS) models the lower plasma omentin- 1 levels was associated with PCOS occurrence, higher circulating TNF-α and lower IL-6 levels.CONCLUSIONS:
Suppressed omentin-1 levels in PCOS are characteristic for this disturbance and proinflammatory cytokines are factors modifying secretion of this adipokine.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
/
Estado Nutricional
/
Citocinas
/
Lectinas
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Obesidade
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article