[A new lignan glucoside from root of Paeonia lactiflora].
Zhongguo Zhong Yao Za Zhi
; 45(12): 2903-2906, 2020 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-32627465
ABSTRACT
A new lignan glucoside,(+)-fragransin A_2-4-O-ß-D-glucopyranoside(1), has been isolated from the dry root of Paeonia lactiflora by column chromatography on silica gel, Sephadex LH-20, and MCI-gel resin, as well as preparative RP-HPLC. The structure of the new compound was elucidated by spectroscopic data analysis(MS, UV, IR, CD, 1 D and 2 D NMR) and chemical method. Compound 1 showed moderate inhibition against lipopolysaccharide induced nitric oxide production in RAW264.7 macrophages, with an IC_(50) value of 21.3 µmol·L~(-1).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lignanas
/
Paeonia
Idioma:
Zh
Ano de publicação:
2020
Tipo de documento:
Article