Identification of unique and shared mitochondrial DNA mutations in neurodegeneration and cancer by single-cell mitochondrial DNA structural variation sequencing (MitoSV-seq).

Jaberi, Elham; Tresse, Emilie; Grønbæk, Kirsten; Weischenfeldt, Joachim; Issazadeh-Navikas, Shohreh

Jaberi, Elham; Tresse, Emilie; Grønbæk, Kirsten; Weischenfeldt, Joachim; Issazadeh-Navikas, Shohreh.

Afiliação

Jaberi E; Neuroinflammation Unit, Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark.
Tresse E; Neuroinflammation Unit, Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark.
Grønbæk K; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark; Department of Hematology, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark; The Danish Stem Cell Center (Danstem), University of Copenha
Weischenfeldt J; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark.
Issazadeh-Navikas S; Neuroinflammation Unit, Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen, Denmark. Electronic address: shohreh.issazadeh@bric.ku.dk.

EBioMedicine ; 57: 102868, 2020 Jul.

Article em En | MEDLINE | ID: mdl-32629384

Assuntos

DNA Mitocondrial/genética; Genoma Mitocondrial/genética; Variação Estrutural do Genoma/genética; Neoplasias/genética; Animais; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Camundongos; Mutação/genética; Neoplasias/patologia; Degeneração Neural/genética; Degeneração Neural/patologia; Polimorfismo de Nucleotídeo Único/genética; Análise de Sequência de DNA; Análise de Célula Única

Palavras-chave

Disease biomarker; Mitochondrial DNA; Neurodegeneration; Neuron; Single-Cell Sequencing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Genoma Mitocondrial / Variação Estrutural do Genoma / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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