Analysis of Innate and Adaptive Immunological Characteristics in Patients with IgG4-Related Disease.
Int Arch Allergy Immunol
; 181(10): 807-812, 2020.
Article
em En
| MEDLINE
| ID: mdl-32629450
ABSTRACT
BACKGROUND:
Immunoglobulin G4-related disease (IgG4-RD) is a systemic immunological disorder characterized by fibro-inflammatory conditions; however, the pathobiology of IgG4-RD has not been fully identified.OBJECTIVE:
This study aimed to analyze systemic differences of innate and adaptive immune cells from healthy controls and patients with IgG4-RD.METHODS:
Healthy controls (n = 9) and IgG4-RD patients (n = 7) were recruited with informed consent. Peripheral blood was collected from healthy controls and IgG4-RD patients, and three blood samples from IgG4-RD patients were re-collected two months after the last rituximab (RTX) treatment. The various immune cells and cytokine productions were measured by flow cytometry.RESULTS:
Blood CD14+ monocytes and steady-state follicular helper T cells were increased in patients with IgG4-RD. However, there were no changes in other immune cell populations, including B cells, CD4 T cells, CD8 T cells, and innate lymphoid cells. Also, the TGF-ß-producing CD14+ monocytes were significantly augmented in patients with IgG4-RD. Two months after RTX treatment, total B cells (CD19+) were depleted; however, the expressions of TGF-ß from CD14+ monocytes remained unchanged.CONCLUSION:
These findings showed that IgG4-RD is related to the increment of CD14+ monocytes. Besides, controlling increased TGF-ß-producing CD14+ monocytes with RTX treatment might be a conducive way to regulate IgG4-RD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucócitos Mononucleares
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Monócitos
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Linfócitos T Auxiliares-Indutores
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Centro Germinativo
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Doença Relacionada a Imunoglobulina G4
Tipo de estudo:
Prognostic_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article