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Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins.
Yan, Nicholas L; Santos-Martins, Diogo; Rennella, Enrico; Sanchez, Brittany B; Chen, Jason S; Kay, Lewis E; Wilson, Ian A; Morgan, Gareth J; Forli, Stefano; Kelly, Jeffery W.
Afiliação
  • Yan NL; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Santos-Martins D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Rennella E; Departments of Molecular Genetics, Biochemistry and Chemistry, The University of Toronto, Toronto, ON M5S1A8, Canada.
  • Sanchez BB; Automated Synthesis Facility, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Chen JS; Automated Synthesis Facility, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Kay LE; Departments of Molecular Genetics, Biochemistry and Chemistry, The University of Toronto, Toronto, ON M5S1A8, Canada; The Hospital for Sick Children, Program in Molecular Medicine, 555 University Avenue, Toronto, ON M5G1X8, Canada.
  • Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Morgan GJ; Section of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA; The Amyloidosis Center, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: gjmorgan@bu.edu.
  • Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: forli@scripps.edu.
  • Kelly JW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: jkelly@scripps.edu.
Bioorg Med Chem Lett ; 30(16): 127356, 2020 08 15.
Article em En | MEDLINE | ID: mdl-32631553

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cadeias Leves de Imunoglobulina / Hidantoínas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cadeias Leves de Imunoglobulina / Hidantoínas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article