Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice.

Shu, Lingling; Zhong, Ling; Xiao, Yang; Wu, Xiaoping; Liu, Yang; Jiang, Xue; Tang, Tao; Hoo, RubyLaiChong; Zhou, Zhiguang; Xu, Aimin

Shu, Lingling; Zhong, Ling; Xiao, Yang; Wu, Xiaoping; Liu, Yang; Jiang, Xue; Tang, Tao; Hoo, RubyLaiChong; Zhou, Zhiguang; Xu, Aimin.

Afiliação

Shu L; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, China.
Zhong L; Department of Hematology Oncology, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Xiao Y; Department of Medicine, The University of Hong Kong, Hong Kong, China.
Wu X; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, China.
Liu Y; Department of Medicine, The University of Hong Kong, Hong Kong, China.
Jiang X; Second Xiangya Hospital, Key Laboratory of Diabetes Immunology, Central South University, National Clinical Research Center for Metabolic Diseases, Changsha, China.
Tang T; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, China.
Hoo R; Department of Pharmacology and Pharmacy, The University of Hong Kong, China.
Zhou Z; Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, China.
Xu A; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, China.

Clin Sci (Lond) ; 134(13): 1679-1696, 2020 07 17.

Article em En | MEDLINE | ID: mdl-32633320

Assuntos

Diabetes Mellitus Tipo 1/enzimologia; Ilhotas Pancreáticas/imunologia; Elastase de Leucócito/imunologia; Animais; Diabetes Mellitus Tipo 1/genética; Diabetes Mellitus Tipo 1/imunologia; Feminino; Humanos; Imunidade Inata; Células Secretoras de Insulina/imunologia; Ilhotas Pancreáticas/enzimologia; Elastase de Leucócito/genética; Camundongos; Camundongos Endogâmicos NOD; Infiltração de Neutrófilos; Neutrófilos/enzimologia; Neutrófilos/imunologia; Linfócitos T Citotóxicos/imunologia

Palavras-chave

autoimmune diabetes; inflammation; innate immunity; neutrophil elastase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Elastase de Leucócito / Diabetes Mellitus Tipo 1 Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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