The Differential Effect of Carbon Dots on Gene Expression and DNA Methylation of Human Embryonic Lung Fibroblasts as a Function of Surface Charge and Dose.

Sima, Michal; Vrbova, Kristyna; Zavodna, Tana; Honkova, Katerina; Chvojkova, Irena; Ambroz, Antonin; Klema, Jiri; Rossnerova, Andrea; Polakova, Katerina; Malina, Tomas; Belza, Jan; Topinka, Jan; Rossner, Pavel

Sima, Michal; Vrbova, Kristyna; Zavodna, Tana; Honkova, Katerina; Chvojkova, Irena; Ambroz, Antonin; Klema, Jiri; Rossnerova, Andrea; Polakova, Katerina; Malina, Tomas; Belza, Jan; Topinka, Jan; Rossner, Pavel.

Afiliação

Sima M; Department of Nanotoxicology and Molecular Epidemiology, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Vrbova K; Department of Nanotoxicology and Molecular Epidemiology, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Zavodna T; Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Honkova K; Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Chvojkova I; Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Ambroz A; Department of Nanotoxicology and Molecular Epidemiology, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Klema J; Department of Computer Science, Czech Technical University in Prague, 12135 Prague, Czech Republic.
Rossnerova A; Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic.
Polakova K; Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University Olomouc, 77146 Olomouc, Czech Republic.
Malina T; Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University Olomouc, 77146 Olomouc, Czech Republic.
Belza J; Department of Physical Chemistry, Faculty of Science, Palacký University Olomouc, 77146 Olomouc, Czech Republic.
Topinka J; Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University Olomouc, 77146 Olomouc, Czech Republic.
Rossner P; Department of Physical Chemistry, Faculty of Science, Palacký University Olomouc, 77146 Olomouc, Czech Republic.

Int J Mol Sci ; 21(13)2020 Jul 04.

Article em En | MEDLINE | ID: mdl-32635498

Assuntos

Carbono/farmacologia; Metilação de DNA/efeitos dos fármacos; Fibroblastos/efeitos dos fármacos; Expressão Gênica/efeitos dos fármacos; Pulmão/efeitos dos fármacos; Apoptose/efeitos dos fármacos; Apoptose/genética; Proliferação de Células/efeitos dos fármacos; Proliferação de Células/genética; Células Cultivadas; Metilação de DNA/genética; Matriz Extracelular/genética; Expressão Gênica/genética; Perfilação da Expressão Gênica/métodos; Humanos; MicroRNAs/genética; Neoplasias/genética; Estresse Oxidativo/efeitos dos fármacos; Estresse Oxidativo/genética; RNA Mensageiro/genética; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética

Palavras-chave

DNA methylation; carbon dots; gene expression; human lung fibroblasts; surface charge

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbono / Expressão Gênica / Metilação de DNA / Fibroblastos / Pulmão Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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