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The aptamer BT200 effectively inhibits von Willebrand factor (VWF) dependent platelet function after stimulated VWF release by desmopressin or endotoxin.
Kovacevic, Katarina D; Buchtele, Nina; Schoergenhofer, Christian; Derhaschnig, Ulla; Gelbenegger, Georg; Brostjan, Christine; Zhu, Shuhao; Gilbert, James C; Jilma, Bernd.
Afiliação
  • Kovacevic KD; Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
  • Buchtele N; Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
  • Schoergenhofer C; Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
  • Derhaschnig U; Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
  • Gelbenegger G; Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
  • Brostjan C; Division of Vascular Surgery and Surgical Research Laboratories, Department of Surgery, Medical University of Vienna, Vienna, Austria.
  • Zhu S; Guardian Therapeutics, Lexington, MA, USA.
  • Gilbert JC; Guardian Therapeutics, Lexington, MA, USA.
  • Jilma B; Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. bernd.jilma@meduniwien.ac.at.
Sci Rep ; 10(1): 11180, 2020 07 07.
Article em En | MEDLINE | ID: mdl-32636459
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Fator de von Willebrand / Agregação Plaquetária / Aptâmeros de Nucleotídeos Tipo de estudo: Etiology_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Fator de von Willebrand / Agregação Plaquetária / Aptâmeros de Nucleotídeos Tipo de estudo: Etiology_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article