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You Say You Want a Resolution (of Fibrosis).
Atabai, Kamran; Yang, Christopher D; Podolsky, Michael J.
Afiliação
  • Atabai K; Cardiovascular Research Institute.
  • Yang CD; Lung Biology Center, and.
  • Podolsky MJ; Department of Medicine, University of California, San Francisco, San Francisco, California.
Am J Respir Cell Mol Biol ; 63(4): 424-435, 2020 10.
Article em En | MEDLINE | ID: mdl-32640171
In pathological fibrosis, aberrant tissue remodeling with excess extracellular matrix leads to organ dysfunction and eventual morbidity. Diseases of fibrosis create significant global health and economic burdens and are often deadly. Although fibrosis has traditionally been thought of as an irreversible process, a growing body of evidence demonstrates that organ fibrosis can reverse in certain circumstances, especially if an underlying cause of injury can be removed. This body of evidence has uncovered more and more contributors to persistent and nonresolving tissue fibrosis. Here, we review the present knowledge on resolution of organ fibrosis and restoration of near-normal tissue architecture. We emphasize three critical areas of tissue homeostasis that are necessary for fibrosis resolution, namely, the elimination of matrix-producing cells, the clearance of excess matrix, and the regeneration of normal tissue constituents. In so doing, we also highlight how profibrotic pathways interact with one another and where there may be therapeutic opportunities to intervene and remediate pathological persistent fibrosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article