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Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library.
Dawadi, Surendra; Simmons, Nicholas; Miklossy, Gabriella; Bohren, Kurt M; Faver, John C; Ucisik, Melek Nihan; Nyshadham, Pranavanand; Yu, Zhifeng; Matzuk, Martin M.
Afiliação
  • Dawadi S; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030 dawadi@bcm.edu mmatzuk@bcm.edu.
  • Simmons N; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Miklossy G; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Bohren KM; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Faver JC; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Ucisik MN; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Nyshadham P; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Yu Z; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030.
  • Matzuk MM; Center for Drug Discovery, Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030 dawadi@bcm.edu mmatzuk@bcm.edu.
Proc Natl Acad Sci U S A ; 117(29): 16782-16789, 2020 07 21.
Article em En | MEDLINE | ID: mdl-32641511
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / DNA / Trombina / Biblioteca Gênica / Bibliotecas de Moléculas Pequenas / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / DNA / Trombina / Biblioteca Gênica / Bibliotecas de Moléculas Pequenas / Descoberta de Drogas Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article