Effect of Chlamydia trachomatis on adverse pregnancy outcomes: a meta-analysis.
Arch Gynecol Obstet
; 302(3): 553-567, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-32643040
ABSTRACT
PURPOSE:
To analyze the effect of Chlamydia trachomatis (C. trachomatis) on adverse pregnancy outcomes based on the currently available evidence.METHODS:
Multiple databases were comprehensively searched from the available date of inception through December 9, 2019. The effect of C. trachomatis on adverse pregnancy outcomes was assessed using pooled odds rations (ORs) and 95% confidence intervals (CIs). Egger's test was used for publication bias.RESULTS:
Fifty studies involving 502,141 participants were identified. C. trachomatis infection was found to be associated with preterm birth in antibody detection [OR (95% CI) 1.571 (1.112-2.220), P = 0.010] and high-quality assessment [OR (95% CI) 1.734 (1.295-2.321), P < 0.001], preterm premature rupture of membranes (PPROM) in culture detection [OR (95% CI) 4.339 (1.806-10.424), P = 0.001] and high-quality assessment [OR (95% CI) 2.822 (1.333-5.973), P = 0.007], stillbirth [OR (95% CI) 1.585 (1.219-2.062), P = 0.001], low-birthweight babies [OR (95% CI) 2.205 (1.137-4.274), P = 0.019], and babies small for gestational age [OR (95% CI) 1.193 (1.091-1.305), P < 0.001]. No publication bias was exhibited in miscarriage (P = 0.170), preterm birth (P = 0.303), PPROM (P = 0.341), stillbirth (P = 0.533), and low-birthweight babies (P = 0.535).CONCLUSIONS:
C. trachomatis infection during pregnancy is associated with a higher risk of preterm birth, PPROM, stillbirth, low-birthweight babies, and babies small for gestational age.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Infecciosas na Gravidez
/
Ruptura Prematura de Membranas Fetais
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Infecções por Chlamydia
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Chlamydia trachomatis
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Trabalho de Parto Prematuro
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
/
Systematic_reviews
Limite:
Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article