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Exosomal miR-1298 and lncRNA-RP11-583F2.2 Expression in Hepato-cellular Carcinoma.
Matboli, Marwa; Labib, Mariam E; Nasser, Hanaa El-Tayeb; El-Tawdi, Ahmed H F; Habib, Eman K; Ali-Labib, Randa.
Afiliação
  • Matboli M; 1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
  • Labib ME; 1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
  • Nasser HE; 1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
  • El-Tawdi AHF; 1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
  • Habib EK; 1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
  • Ali-Labib R; 1Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11381, Egypt; 2General and Plastic Surgery Department, Military Medical Academy, Cairo, Egypt; 3Anatomy Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
Curr Genomics ; 21(1): 46-55, 2020 Jan.
Article em En | MEDLINE | ID: mdl-32655298
AIM: The aim of this study was to explore the expression of exosomal non-coding RNAs (ncRNAs) in the sera of patients with HCC versus control. METHODS: Firstly, Bioinformatics analysis was conducted to retrieve ncRNAs specific to HCC (hsa-miRNA-1298 and lncRNA-RP11-583F2.2). Afterwards, extraction and characterization of exosomes were performed. We measured the expression of the chosen exosomal RNAs by reverse transcriptase quantitative real-time PCR in sera of 60 patients with HCC, 42 patients with chronic hepatitis C (CHC) infection and 18 healthy normal volunteers. RESULTS: The exosomal ncRNAs [hsa-miRNA-1298, lncRNA-RP11-583F2.2] had better sensitivity and specificity than alpha-fetoprotein (AFP) in HCC diagnosis. CONCLUSION: The exosomal hsa-miRNA-1298, lncRNA-RP11-583F2.2 can be potential biomarkers for HCC diagnosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article