Genetic disruption of the inflammasome adaptor ASC has minimal impact on the pathogenesis of Duchenne muscular dystrophy in mdx mice.

Lau, Yeh Siang; Zhao, Lixia; Zhang, Chen; Li, Haiwen; Han, Renzhi

Lau, Yeh Siang; Zhao, Lixia; Zhang, Chen; Li, Haiwen; Han, Renzhi.

Afiliação

Lau YS; Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Zhao L; Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Zhang C; Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Li H; Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.
Han R; Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States. Electronic address: renzhi.han@osumc.edu.

Life Sci ; 257: 118069, 2020 Sep 15.

Article em En | MEDLINE | ID: mdl-32659370

Assuntos

Proteínas Adaptadoras de Sinalização CARD/genética; Distrofina/genética; Inflamassomos/metabolismo; Distrofia Muscular de Duchenne/fisiopatologia; Animais; Citocinas/sangue; Modelos Animais de Doenças; Progressão da Doença; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos mdx; Camundongos Knockout; Distrofia Muscular de Duchenne/genética; Regulação para Cima

Palavras-chave

ASC; DMD; Inflammasome; Inflammation; Muscle regeneration; mdx mice

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Distrofina / Distrofia Muscular de Duchenne / Proteínas Adaptadoras de Sinalização CARD / Inflamassomos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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