The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.

Ravala, Sandeep K; Hopkins, Jesse B; Plescia, Caroline B; Allgood, Samantha R; Kane, Madison A; Cash, Jennifer N; Stahelin, Robert V; Tesmer, John J G

Ravala, Sandeep K; Hopkins, Jesse B; Plescia, Caroline B; Allgood, Samantha R; Kane, Madison A; Cash, Jennifer N; Stahelin, Robert V; Tesmer, John J G.

Afiliação

Ravala SK; Departments of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Hopkins JB; The Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, USA.
Plescia CB; Biophysics Collaborative Access Team, Illinois Institute of Technology, Advanced Photon Source, Argonne National Laboratory, Lemont, Illinois, USA.
Allgood SR; The Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, USA.
Kane MA; Departments of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Cash JN; College of Engineering, California State University, Long Beach, California, USA.
Stahelin RV; Department of Biological Chemistry & Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA.
Tesmer JJG; The Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, USA.

J Biol Chem ; 295(36): 12635-12647, 2020 09 04.

Article em En | MEDLINE | ID: mdl-32661198

Assuntos

Membrana Celular; Fatores de Troca do Nucleotídeo Guanina; Membrana Celular/química; Membrana Celular/genética; Membrana Celular/metabolismo; Proteínas Quinases Dependentes de AMP Cíclico/química; Proteínas Quinases Dependentes de AMP Cíclico/genética; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Fatores de Troca do Nucleotídeo Guanina/química; Fatores de Troca do Nucleotídeo Guanina/genética; Fatores de Troca do Nucleotídeo Guanina/metabolismo; Humanos; Fosforilação; Domínios Proteicos

Palavras-chave

Egl-10; SAXS (small-angle X-ray scattering); allosteric regulation; and pleckstrin (DEP) domain; binding protein; cell signaling; crystallography; dishevelled; enzyme inactivation; guanine nucleotide exchange factor; guanine nucleotide exchange factor (GEF); lipid signaling; lipid-protein interaction; oncogene; phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 (P-Rex1); protein kinase A (PKA); protein phosphorylation; protein-lipid interaction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membrana Celular / Fatores de Troca do Nucleotídeo Guanina Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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