Distinguishing paracetamol formulations: Comparison of potentiometric "Electronic Tongue" with established analytical techniques.
J Pharm Biomed Anal
; 188: 113457, 2020 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-32663766
ABSTRACT
Fast and inexpensive analytical tools for identification of the origin of pharmaceutical formulations are important to ensure consumers safety. This study explores the potential of potentiometric multisensor systems ("electronic tongues") in this type of application. 72 paracetamol samples purchased in different countries and produced by various companies were studied via infrared spectroscopy (IR), near infrared spectroscopy (NIR), nuclear magnetic resonance spectroscopy (NMR) and multisensor system (ET). A variety of chemometric tools was applied to explore and compare the information yielded by these methods. It was found that ET is capable of distinguishing paracetamol formulations from different producers. The chemical information derived from potentiometric sensor responses has something in common with that derived from NIR and IR; however, it is orthogonal to that from NMR. ET can be a valuable tool in express quality assessment of drugs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nariz Eletrônico
/
Acetaminofen
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article