Hyperthyroxinemia and Hypercortisolemia due to Familial Dysalbuminemia.
Thyroid
; 30(11): 1681-1684, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32669045
ABSTRACT
A 23-year-old man and his grandmother with hyperthyroxinemia and hypercortisolemia were heterozygous for an ALB mutation (p. Arg218Pro), known to cause familial dysalbuminemic hyperthyroxinemia (FDH). However, serum-free cortisol levels in these individuals were normal and total cortisol concentrations fell markedly after depletion of albumin from their serum. We conclude that binding of steroid as well as iodothyronines to mutant albumin causes raised circulating cortisol as well as thyroid hormones in euthyroid euadrenal individuals with R218P FDH, with potential for misdiagnosis, unnecessary investigation, and inappropriate treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipertireoxinemia
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Hidrocortisona
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Hipertireoxinemia Disalbuminêmica Familiar
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Albumina Sérica Humana
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Mutação
Limite:
Adult
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Humans
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article