Phytosterols demonstrate selective inhibition of COX-2: In-vivo and in-silico studies of Nicotiana tabacum.

Akinloye, O Adeboye; Akinloye, D Ibukun; Onigbinde, S Bamidele; Metibemu, D Samuel

Akinloye, O Adeboye; Akinloye, D Ibukun; Onigbinde, S Bamidele; Metibemu, D Samuel.

Afiliação

Akinloye OA; Department of Biochemistry, Phytomedicine, Phyto-chemistry and Bio-computing Research Laboratory, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.
Akinloye DI; Department of Biochemistry, Phytomedicine, Phyto-chemistry and Bio-computing Research Laboratory, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.
Onigbinde SB; Department of Biochemistry, Phytomedicine, Phyto-chemistry and Bio-computing Research Laboratory, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.
Metibemu DS; Department of Biochemistry, Phytomedicine, Phyto-chemistry and Bio-computing Research Laboratory, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria; Department of Biochemistry, Faculty of Science, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria. Electronic a

Bioorg Chem ; 102: 104037, 2020 09.

Article em En | MEDLINE | ID: mdl-32707278

Assuntos

Anti-Inflamatórios/uso terapêutico; Inibidores de Ciclo-Oxigenase 2/uso terapêutico; Ensaios de Triagem em Larga Escala/métodos; Simulação de Acoplamento Molecular/métodos; Nicotiana/química; Fitosteróis/uso terapêutico; Animais; Anti-Inflamatórios/farmacologia; Simulação por Computador; Humanos; Masculino; Camundongos; Fitosteróis/farmacologia; Ratos Wistar

Palavras-chave

Anti-inflammation; Cyclooxygenase -1 (COX-1) and cyclooxygenase -2 (COX-2); Molecular Docking; Phytosterols; Virtual High Throughput Screening (vHTS)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fitosteróis / Nicotiana / Inibidores de Ciclo-Oxigenase 2 / Ensaios de Triagem em Larga Escala / Simulação de Acoplamento Molecular / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google