Statins in COVID-19: is there any foundation? / Estatinas en COVID-19: ¿existe algún fundamento?
Clin Investig Arterioscler
; 32(6): 278-281, 2020.
Article
em En, Es
| MEDLINE
| ID: mdl-32718669
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causal agent of coronavirus disease 2019 (COVID-19). Acute respiratory distress syndrome is the main cause of death from COVID-19 and occurs due to an exaggerated inflammatory response that causes the release of pro-inflammatory cytokines such as interleukins and tumor necrosis factor-alpha (TNF-α). Statins are lipid lowering drugs with pleiotropic effects. They have shown benefit in the management of inflammatory and autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis. Furthermore, due to their immunomodulatory properties, they have been used in the treatment of various infectious diseases such as community-acquired pneumonia and influenza. In this review we analyze the pathophysiological foundations that support the use of statins as an adjunctive treatment in patients with COVID-19.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Hidroximetilglutaril-CoA Redutases
/
SARS-CoV-2
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Tratamento Farmacológico da COVID-19
Limite:
Humans
Idioma:
En
/
Es
Ano de publicação:
2020
Tipo de documento:
Article