A revised mechanism for (p)ppGpp synthesis by Rel proteins: The critical role of the 2'-OH of GTP.

Patil, Pratik Rajendra; Vithani, Neha; Singh, Virender; Kumar, Ashok; Prakash, Balaji

Patil, Pratik Rajendra; Vithani, Neha; Singh, Virender; Kumar, Ashok; Prakash, Balaji.

Afiliação

Patil PR; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Vithani N; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Singh V; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Kumar A; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Prakash B; Department of Molecular Nutrition, Council of Scientific and Industrial Research-Central Food Technological Research Institute, Mysore, India. Electronic address: bprakashiit@gmail.com.

J Biol Chem ; 295(37): 12851-12867, 2020 09 11.

Article em En | MEDLINE | ID: mdl-32719004

Assuntos

Proteínas de Bactérias/metabolismo; Regulação Bacteriana da Expressão Gênica; Guanosina Pentafosfato/biossíntese; Guanosina Trifosfato/metabolismo; Ligases/metabolismo; Streptococcus/metabolismo; Proteínas de Bactérias/genética; Guanosina Pentafosfato/genética; Guanosina Trifosfato/genética; Ligases/genética; Magnésio/metabolismo; Streptococcus/genética

Palavras-chave

(p)ppGpp; (p)ppGpp synthesis; 2'-OH; ATP; GTP; Rel proteins; enzyme mechanism; fluorescence resonance energy transfer (FRET); isothermal titration calorimetry (ITC); pyrophosphate transfer; stress response

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Streptococcus / Proteínas de Bactérias / Regulação Bacteriana da Expressão Gênica / Guanosina Pentafosfato / Guanosina Trifosfato / Ligases Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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