Haplotype networks of SARS-CoV-2 infections in the Diamond Princess cruise ship outbreak.
Proc Natl Acad Sci U S A
; 117(33): 20198-20201, 2020 08 18.
Article
em En
| MEDLINE
| ID: mdl-32723824
ABSTRACT
The Diamond Princess cruise ship was put under quarantine offshore Yokohama, Japan, after a passenger who disembarked in Hong Kong was confirmed as a coronavirus disease 2019 case. We performed whole-genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly from PCR+ clinical specimens and conducted a phylogenetic analysis of the outbreak. All tested isolates exhibited a transversion at G11083T, suggesting that SARS-CoV-2 dissemination on the Diamond Princess originated from a single introduction event before the quarantine started. Although further spreading might have been prevented by quarantine, some progeny clusters could be linked to transmission through mass-gathering events in the recreational areas and direct transmission among passengers who shared cabins during the quarantine. This study demonstrates the usefulness of haplotype network/phylogeny analysis in identifying potential infection routes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Filogenia
/
Pneumonia Viral
/
Navios
/
Haplótipos
/
Genoma Viral
/
Infecções por Coronavirus
/
Betacoronavirus
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article