Novel Bacillus strains from the human gut exert anticancer effects on a broad range of malignancy types.
Invest New Drugs
; 38(5): 1373-1382, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32734371
ABSTRACT
Cancer is one of the leading causes of death worldwide, but effective therapies remain the topic of many research activities. Many recent studies have thus focused on particular gut microbiota due to their important roles in treating cancers, but very few microbes of therapeutic value have been reported. In this study, we isolated four bacterial strains, BY38, BY40, BY43 and BY45, from the fecal specimens of healthy individuals and cancer patients. The treatment of cancer cells with the products of these cultured bacteria induced significant inhibitory effects on the proliferation of ovarian cancer cells and colorectal cancer cells in a dose-dependent manner. A phylogenetic analysis showed that the four anticancer strains belong to the genus Bacillus, and flow cytometry assays indicated that the inhibitory effects might be achieved through the induction of cell apoptosis. These results suggest that these bacteria could be novel and promising anticancer agents against cancers.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bacillus
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Produtos Biológicos
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Microbioma Gastrointestinal
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Neoplasias
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Antineoplásicos
Limite:
Adult
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article