Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses.
Antiviral Res
; 182: 104874, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32735900
ABSTRACT
Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-ß (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus de RNA
/
Replicação Viral
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DNA Topoisomerases Tipo I
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Betacoronavirus
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article