(E<sub>X</sub>-4)<sub>2</sub>-Fc, an effective long-acting GLP-1 receptor agonist, reduces obesity-related inflammation by inhibiting leptin expression.

Zhou, Bailing; Dong, Chunyan; Zhao, Binyan; Su, Xiaoqing; Luo, Yi; Xie, Li; Tian, Yaomei; Zhang, Rui; Yang, Li

(E_X-4)₂-Fc, an effective long-acting GLP-1 receptor agonist, reduces obesity-related inflammation by inhibiting leptin expression.

Zhou, Bailing; Dong, Chunyan; Zhao, Binyan; Su, Xiaoqing; Luo, Yi; Xie, Li; Tian, Yaomei; Zhang, Rui; Yang, Li.

Afiliação

Zhou B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Dong C; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Zhao B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Su X; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Luo Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Xie L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Tian Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Zhang R; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China.
Yang L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China. Electronic address: yl.tracy73@gmail.com.

Biochem Biophys Res Commun ; 529(3): 562-568, 2020 08 27.

Article em En | MEDLINE | ID: mdl-32736674

Assuntos

Tecido Adiposo/efeitos dos fármacos; Peptídeo 1 Semelhante ao Glucagon/farmacologia; Receptor do Peptídeo Semelhante ao Glucagon 1/agonistas; Inflamação/prevenção & controle; Leptina/antagonistas & inibidores; Obesidade/metabolismo; Tecido Adiposo/citologia; Tecido Adiposo/metabolismo; Animais; Anti-Inflamatórios/farmacologia; Citocinas/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Dieta Hiperlipídica/efeitos adversos; Peptídeo 1 Semelhante ao Glucagon/química; Inflamação/metabolismo; Leptina/metabolismo; Ativação de Macrófagos/efeitos dos fármacos; Macrófagos/classificação; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Camundongos Obesos; NF-kappa B/metabolismo; Obesidade/etiologia; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

(Ex-4)(2)-Fc; Inflammation; Leptin; Obesity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecido Adiposo / Leptina / Peptídeo 1 Semelhante ao Glucagon / Receptor do Peptídeo Semelhante ao Glucagon 1 / Inflamação / Obesidade Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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