p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers.

Sano, Hitoya; Futamura, Manabu; Gaowa, Siqin; Kamino, Hiroki; Nakamura, Yasuyuki; Yamaguchi, Kazuya; Tanaka, Yoshihiro; Yasufuku, Itaru; Nakakami, Akira; Arakawa, Hirofumi; Yoshida, Kazuhiro

Sano, Hitoya; Futamura, Manabu; Gaowa, Siqin; Kamino, Hiroki; Nakamura, Yasuyuki; Yamaguchi, Kazuya; Tanaka, Yoshihiro; Yasufuku, Itaru; Nakakami, Akira; Arakawa, Hirofumi; Yoshida, Kazuhiro.

Afiliação

Sano H; Department of Surgical Oncology, Gifu University, Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Futamura M; Department of Surgical Oncology, Gifu University, Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: mfutamur@gifu-u.ac.jp.
Gaowa S; Department of Surgical Oncology, Gifu University, Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Kamino H; Division of Cancer Biology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Nakamura Y; Division of Cancer Biology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Yamaguchi K; Department of Surgical Oncology, Gifu University, Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Tanaka Y; Department of Surgical Oncology, Gifu University, Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Yasufuku I; Department of Surgical Oncology, Gifu University, Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Nakakami A; Department of Surgical Oncology, Gifu University, Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.
Arakawa H; Division of Cancer Biology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. Electronic address: harakawa@ncc.go.jp.
Yoshida K; Department of Surgical Oncology, Gifu University, Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

Biochem Biophys Res Commun ; 529(3): 582-589, 2020 08 27.

Article em En | MEDLINE | ID: mdl-32736677

Assuntos

Mitocôndrias/metabolismo; Proteínas Mitocondriais/metabolismo; Neoplasias Gástricas/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Proteínas Supressoras de Tumor/metabolismo; Idoso; Apoptose/genética; Caspases/metabolismo; Linhagem Celular Tumoral; Metilação de DNA; Feminino; Regulação Neoplásica da Expressão Gênica; Humanos; Masculino; Mitocôndrias/genética; Proteínas Mitocondriais/genética; Mutação; Regiões Promotoras Genéticas/genética; Transdução de Sinais/genética; Neoplasias Gástricas/genética; Neoplasias Gástricas/patologia; Proteína Supressora de Tumor p53/genética; Proteínas Supressoras de Tumor/genética

Palavras-chave

Caspase; Esophageal cancer; Gastric cancer; Mieap; Promoter methylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Proteína Supressora de Tumor p53 / Proteínas Mitocondriais / Proteínas Supressoras de Tumor / Mitocôndrias Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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