Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction.

Umehara, Kenichi; Cantrill, Carina; Wittwer, Matthias Beat; Di Lenarda, Elisa; Klammers, Florian; Ekiciler, Aynur; Parrott, Neil; Fowler, Stephen; Ullah, Mohammed

Umehara, Kenichi; Cantrill, Carina; Wittwer, Matthias Beat; Di Lenarda, Elisa; Klammers, Florian; Ekiciler, Aynur; Parrott, Neil; Fowler, Stephen; Ullah, Mohammed.

Afiliação

Umehara K; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland kenichi.umehara@roche.com.
Cantrill C; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Wittwer MB; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Di Lenarda E; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Klammers F; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Ekiciler A; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Parrott N; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Fowler S; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Ullah M; Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel, Switzerland.

Drug Metab Dispos ; 48(10): 849-860, 2020 10.

Article em En | MEDLINE | ID: mdl-32739889

Assuntos

Desenvolvimento de Medicamentos/métodos; Descoberta de Drogas/métodos; Modelos Biológicos; Células Cultivadas; Técnicas de Cocultura; Feminino; Hepatócitos; Humanos; Masculino; Taxa de Depuração Metabólica; Cultura Primária de Células

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Descoberta de Drogas / Desenvolvimento de Medicamentos / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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