The Risk of Dementia in Relation to Cognitive and Brain Reserve.
J Alzheimers Dis
; 77(2): 607-618, 2020.
Article
em En
| MEDLINE
| ID: mdl-32741820
ABSTRACT
BACKGROUND:
Individual differences in the risk to develop dementia remain poorly understood. These differences may partly be explained through reserve, which is the ability to buffer cognitive decline due to neuropathology and age.OBJECTIVE:
To determine how much early and late-life cognitive reserve (CR) and brain reserve (BR) contribute to the risk of dementia.METHODS:
4,112 dementia-free participants (mean ageâ=â66.3 years) from the Rotterdam Study were followed up for on average 6.0 years. Early-life CR and BR were defined as attained education and intracranial volume, respectively. Late-life CR was derived through variance decomposition based on cognition. Late-life BR was set as the total non-lesioned brain volume divided by intracranial volume.RESULTS:
Higher early-life CR (hazard ratioâ=â0.48, 95% CIâ=â[0.21; 1.06]) but not early-life BR associated with a lower risk of incident dementia. Higher late-life CR (hazard ratioâ=â0.57, 95% CIâ=â[0.48; 0.68]) and late-life BR (hazard ratioâ=â0.54, 95% CIâ=â[0.43; 0.68]) also showed lower levels of dementia. Combining all proxies into one model attenuated the association between early-life CR and dementia (hazard ratioâ=â0.56, 95% CIâ=â[0.25; 1.25]) whereas the other associations were unaffected. These findings were stable upon stratification for sex, age, and APOEÉ4. Finally, high levels of late-life CR and BR provided additive protection against dementia.CONCLUSION:
The findings illustrate the importance of late-life over early-life reserve in understanding the risk of dementia, and show the need to study CR and BR conjointly.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Demência
/
Reserva Cognitiva
/
Disfunção Cognitiva
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article