Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia.

Leung, Kit-Yi; De Castro, Sandra C P; Santos, Chloe; Savery, Dawn; Prunty, Helen; Gold-Diaz, Diana; Bennett, Stuart; Heales, Simon; Copp, Andrew J; Greene, Nicholas D E

Leung, Kit-Yi; De Castro, Sandra C P; Santos, Chloe; Savery, Dawn; Prunty, Helen; Gold-Diaz, Diana; Bennett, Stuart; Heales, Simon; Copp, Andrew J; Greene, Nicholas D E.

Afiliação

Leung KY; Great Ormond Street Institute of Child Health, University College London, London, UK.
De Castro SCP; Great Ormond Street Institute of Child Health, University College London, London, UK.
Santos C; Great Ormond Street Institute of Child Health, University College London, London, UK.
Savery D; Great Ormond Street Institute of Child Health, University College London, London, UK.
Prunty H; Department of Chemical Pathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Gold-Diaz D; Great Ormond Street Institute of Child Health, University College London, London, UK.
Bennett S; Department of Chemical Pathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Heales S; Great Ormond Street Institute of Child Health, University College London, London, UK.
Copp AJ; Department of Chemical Pathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Greene NDE; Great Ormond Street Institute of Child Health, University College London, London, UK.

J Inherit Metab Dis ; 43(6): 1186-1198, 2020 11.

Article em En | MEDLINE | ID: mdl-32743799

Assuntos

Encéfalo/metabolismo; Glicina Desidrogenase (Descarboxilante)/genética; Glicina/metabolismo; Hiperglicinemia não Cetótica/enzimologia; Alelos; Animais; Encéfalo/patologia; Hiperglicinemia não Cetótica/patologia; Camundongos; Mutação de Sentido Incorreto

Palavras-chave

benzoate; cinnamate; glycine cleavage system; glycine conjugation; glycine decarboxylase; non-ketotic hyperglycinemia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Hiperglicinemia não Cetótica / Glicina Desidrogenase (Descarboxilante) / Glicina Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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